The respiration of oxygen, while essential to aerobic organisms for the generation of energy, leads to the formation of reactive oxygen intermediates (ROIs) as harmful byproducts. ROIs damage nucleic acids, lipids and proteins. Therefore, protective mechanisms against elevated intracellular ROI levels, referred to as oxidative stress, have evolved. These include the activation of transcription factors which elevate the expression of protective enzymes. Eukaryotic cells have also evolved the ability to specifically generate ROIs are used as second messengers to activate gene (...) expression. Here we will discuss both prokaryotic and eukaryotic transcription factors that respond to ROIs. In addition, transcription factors will be described that are activated by either exposure to antioxidants, which reduce the intracellular ROI concentration, or by hypoxia, the absence of oxygen. (shrink)

Sociologists who use in-depth interview methods have become sensitized to the ways that race-ethnicity and class can form barriers to rapport with respondents, but the question of gender has been largely unexamined. This article compares data from two independently conducted in-depth interview studies of male nurses: one by a female researcher and one by a male researcher. Observed differences in how the men in the samples framed their responses to questions in the two studies are discussed. It is argued that (...) in-depth interviewers can and should become sensitized to respondents' negotiation of the gendered context of the interaction, but the existing proscriptions against cross-gender research are challenged. (shrink)

We prove the consistency result from the title. By forcing we construct a model of g = ℵ l , b = cf(Sym(ω)) = ℵ 2.

Answering some of the main questions from [L. Motto Ros, The descriptive set-theoretical complexity of the embeddability relation on models of large size, Ann. Pure Appl. Logic164(12) (2013) 1454–1492], we show that whenever κ is a cardinal satisfying κ<κ=κ>ω, then the embeddability relation between κ-sized structures is strongly invariantly universal, and hence complete for (κ-)analytic quasi-orders. We also prove that in the above result we can further restrict our attention to various natural classes of structures, including (generalized) trees, graphs, or (...) groups. This fully generalizes to the uncountable case the main results of [A. Louveau and C. Rosendal, Complete analytic equivalence relations, Trans. Amer. Math. Soc.357(12) (2005) 4839–4866; S.-D. Friedman and L. Motto Ros, Analytic equivalence relations and bi-embeddability, J. Symbolic Logic76(1) (2011) 243–266; J. Williams, Universal countable Borel quasi-orders, J. Symbolic Logic79(3) (2014) 928–954; F. Calderoni and L. Motto Ros, Universality of group embeddability, Proc. Amer. Math. Soc.146 (2018) 1765–1780]. (shrink)

" La science avance plus vite que l'homme ". La formule de François Mitterrand se révèle, chaque jour davantage en matière de bioéthique, d'une étonnante actualité! Alors qu'il est encore bien malaisé de porter un jugement éthique et juridique sur le développement des biotechnologies, chacun s'interroge sur la justification et les risques des techniques les plus récentes, les perspectives qu'elles ouvrent à l'homme, mais également leur compatibilité avec la dignité de la personne. Lors d'un colloque pluridisciplinaire et international organisé par (...) la Faculté de droit de Nancy, le Centre Juridique Franco-Allemand et le Groupe de recherche de droit médical de l'Université de la Sarre, juristes, philosophes et médecins se sont penchés ensemble sur ces questions essentielles. Leurs réflexions et les discussions qu'elles ont engendrées, à la lumière des sensibilités française et allemande, font l'objet du présent ouvrage. En langue française, les diverses contributions sont suivies d'un résumé en allemand. Les fulgurants progrès des biotechnologies offrent incontestablement à l'humanité des chances nouvelles. Mais face à des biologistes dont certains se prennent déjà pour Dieu, il devient d'une urgente nécessité de réaffirmer les Droits de l'Homme. Qu'il s'agisse de procréation médicalement assistée, de thérapie génique ou d'expérimentation sur l'homme, une conclusion s'impose : lorsqu'elle menace la dignité de la personne, la liberté de la Science doit être limitée. L'avenir de l'espèce humaine est peut-être à ce prix... (shrink)

What constitutes our number concept? What makes it possible for us to employ numbers the way we do; which mental faculties contribute to our grasp of numbers? What do we share with other species, and what is specific to humans? How does our language faculty come into the picture? This 2003 book addresses these questions and discusses the relationship between numerical thinking and the human language faculty, providing psychological, linguistic and philosophical perspectives on number, its evolution and its development in (...) children. Heike Wiese argues that language as a human faculty plays a crucial role in the emergence of systematic numerical thinking. She characterises number sequences as powerful and highly flexible mental tools that are unique to humans and shows that it is language that enables us to go beyond the perception of numerosity and to develop such mental tools. (shrink)

In this article, we develop the concept of Transparency by Design that serves as practical guidance in helping promote the beneficial functions of transparency while mitigating its challenges in automated-decision making environments. With the rise of artificial intelligence and the ability of AI systems to make automated and self-learned decisions, a call for transparency of how such systems reach decisions has echoed within academic and policy circles. The term transparency, however, relates to multiple concepts, fulfills many functions, and holds different (...) promises that struggle to be realized in concrete applications. Indeed, the complexity of transparency for ADM shows tension between transparency as a normative ideal and its translation to practical application. To address this tension, we first conduct a review of transparency, analyzing its challenges and limitations concerning automated decision-making practices. We then look at the lessons learned from the development of Privacy by Design, as a basis for developing the Transparency by Design principles. Finally, we propose a set of nine principles to cover relevant contextual, technical, informational, and stakeholder-sensitive considerations. Transparency by Design is a model that helps organizations design transparent AI systems, by integrating these principles in a step-by-step manner and as an ex-ante value, not as an afterthought. (shrink)

Despite decades of management and conservation efforts, we have seen only limited success in rebuilding marine life and restoring ocean ecosystems from human-inflicted damage on a global scale. I suggest that we need to harness both our emotional and rational sides to create a more powerful movement to heal the ocean and rebuild its abundance and diversity. Love and compassion fuel our desire and urge for change and provide a compass that can guide our actions. Science and knowledge provide ways (...) for collecting and interpreting data and information that can enhance our understanding and support our decisions and actions. Combining our emotional and rational sides can inspire our thinking and transform our actions in new, creative ways. In order to affect wide-ranging and long-lasting change, love and knowledge need to work together to transform our collective relationship with the ocean. (shrink)

Poetisierende Musikbeschreibungen werden von der Wissenschaft, von Musikern und Konzertbesuchern heute mehr belächelt als ernst genommen. Durch das Ansprechen von Einbildungskraft und Gefühl haben sie aber eine Unmittelbarkeit, die der kompositionstechnischen Analyse in der Regel fehlt. Die Wurzeln einer metaphorischen Musikbeschreibung um die Wende zum 19. Jahrhundert sind dabei gleichermaßen historisch wie systematisch zu fassen. Zahlreiche Zitate aus den Fachzeitschriften bis zur Jahrhundertmitte dokumentieren die Herausbildung eines festumrissenen Bildervorrats, um musikalische Eindrücke zur Sprache zu bringen. Der kreative Umgang mit Beschreibungskonventionen (...) ist für die Musikkritiken von E.T.A. Hoffmann, Adolf Bernhard Marx, Ludwig Rellstab und vor allem Robert Schumann kennzeichnend. (shrink)

We argue for a perspective on bilingual heritage speakers as native speakers of both their languages and present results from a large-scale, cross-linguistic study that took such a perspective and approached bilinguals and monolinguals on equal grounds. We targeted comparable language use in bilingual and monolingual speakers, crucially covering broader repertoires than just formal language. A main database was the open-access RUEG corpus, which covers comparable informal vs. formal and spoken vs. written productions by adolescent and adult bilinguals with heritage-Greek, (...) -Russian, and -Turkish in Germany and the United States and with heritage-German in the United States, and matching data from monolinguals in Germany, the United States, Greece, Russia, and Turkey. Our main results lie in three areas. We found non-canonical patterns not only in bilingual, but also in monolingual speakers, including patterns that have so far been considered absent from native grammars, in domains of morphology, syntax, intonation, and pragmatics. We found a degree of lexical and morphosyntactic inter-speaker variability in monolinguals that was sometimes higher than that of bilinguals, further challenging the model of the streamlined native speaker. In majority language use, non-canonical patterns were dominant in spoken and/or informal registers, and this was true for monolinguals and bilinguals. In some cases, bilingual speakers were leading quantitatively. In heritage settings where the language was not part of formal schooling, we found tendencies of register leveling, presumably due to the fact that speakers had limited access to formal registers of the heritage language. Our findings thus indicate possible quantitative differences and different register distributions rather than distinct grammatical patterns in bilingual and monolingual speakers. This supports the integration of heritage speakers into the native-speaker continuum. Approaching heritage speakers from this perspective helps us to better understand the empirical data and can shed light on language variation and change in native grammars. Furthermore, our findings for monolinguals lead us to reconsider the state-of-the art on majority languages, given recurring evidence for non-canonical patterns that deviate from what has been assumed in the literature so far, and might have been attributed to bilingualism had we not included informal and spoken registers in monolinguals and bilinguals alike. (shrink)

We give an affirmative answer to Brendle's and Hrušák's question of whether the club principle together with h > N₁ is consistent. We work with a class of axiom A forcings with countable conditions such that q ≥ n p is determined by finitely many elements in the conditions p and q and that all strengthenings of a condition are subsets, and replace many names by actual sets. There are two types of technique: one for tree-like forcings and one for (...) forcings with creatures that are translated into trees. Both lead to new models of the club principle. (shrink)

Nachdem der Zusammenhang zwischen Sprache und Emotion in der Linguistik lange Zeit vernachlässigt wurde, erhält diese Frage seit etwa 25 Jahren so hohe Aufmerksamkeit, dass von einem 'emotional turn' gesprochen werden kann. Der vorliegende Band dient als Zusammenfassung des aktuellen Forschungsstandes zu diesem komplexen Thema. Berücksichtigt werden Erkenntnisse aus verschiedenen Teildisziplinen, z.B. Semiotik, Lexikologie, Pragmatik, Kognitive Linguistik und Textlinguistik. Im methodischen Teil wird gezeigt, wie eine emotionslinguistische Analyse emotive Strukturen in Texten offenlegen kann, wobei die vorgeschlagene Methode leicht an verschiedene (...) Fragestellungen angepasst werden kann. Die empirische Überprüfung ergibt einen Vergleich von drei sehr unterschiedlichen Textkorpora: Untersucht werden Briefe von Franz Kafka als Beispiel für einen Individualstil, Nachrichtenartikel von verschiedenen Online-Plattformen als Beispiel für Medientexte und die Kommunikationsform Twitter als Beispiel für Online-Kommunikation. Forschende, Lehrende und Studierende finden hier sowohl einen umfassenden Überblick über theoretische Grundlagen als auch Anregungen für die Anwendung in der eigenen Forschung und Lehre. (shrink)

This paper provides an introduction to ethical issues arising in children's research that takes place in school-settings. It addresses three main areas of ethical concern: the informed consent process, confidentiality, and harm and benefit. Informed consent in school settings is characterized by the involvement of multiple stakeholders, including not just researchers, parents and individual children but also school principals, teachers and the children's peer group. The added complexity of the setting has implications for the management of the informed consent process, (...) including the decision at what point and in which manner each stakeholder group needs to be involved in the process. The presence and divergent roles of these multiple stakeholders in the school setting also have implications for addressing issues of confidentiality, especially due to the group setting in which participants take part in the research and role expectations within school settings. Harm and benefit in school-based research are of a non-physical nature; relevant areas of concern relate primarily to the potential for psychological and social harm, realistic presentation of likely benefits from research and the issue of rewards for research participation. (shrink)

Intervening in the multidisciplinary debate on emotion, Tropes of Transport offers a fresh analysis of Hegel’s work that becomes an important resource for Pahl’s cutting-edge theory of emotionality. If it is usually assumed that the sincerity of emotions and the force of affects depend on their immediacy, Pahl explores to what extent mediation—and therefore a certain degree of manipulation but also of sympathy—is constitutive of emotionality. Hegel serves as a particularly helpful interlocutor not only because he offers a (...) sophisticated analysis of mediation, but also because, rather than locating emotion in the heart, he introduces impersonal tropes of transport, such as trembling, release, and shattering. (shrink)

It is consistent that each union of many families in the Baire space which are not finitely dominating is not dominating. In particular, it is consistent that for each nonprincipal ultrafilter , the cofinality of the reduced ultrapower is greater than . The model is constructed by oracle chain condition forcing, to which we give a self-contained introduction.

The article takes Helmuth Plessner’s Political Anthropology from 1931 as a postfoundationalist theory of society avant la lettre - which is very similar to the later works of Claude Lefort, Ernesto Laclau, and Chantal Mouffe. Or, the article takes Plessner’s essay as an ‘ontology’ of the Political. After introducing remarks on the historical debates, in which Plessner aimed to intervene, his theory of the Political is reconstructed, within the three categories of ‘unfathomability’, of the constitutive outside, and of the vulnerability (...) of the human body. In a third and last step, Plessner’s most central and most problematic category for the Political - the ‘popular existence’ - is discussed: The ‘people’ is made visible as being a key notion of postfoundational theories of modern democracy, for it is - beneath the ‘Individual’ - one of the imaginary foundations, one of the foundational outsides of a democratically instituted collective. (shrink)

The article explores the underlying reasons for patients’ self‐perception of being a burden (SPB) in family settings, including its impact on relationships when wishes to die (WTD) are expressed. In a prospective, interview‐based study of WTD in patients with advanced cancer and non‐cancer disease (organ failure, degenerative neurological disease, and frailty) SPB was an important emerging theme. In a sub‐analysis we examined (a) the facets of SPB, (b) correlations between SPB and WTD, and (c) SPB as a relational phenomenon. We (...) analyzed 248 interviews with 62 patients, their family caregivers, and professionals using grounded theory and interpretive phenomenological analysis. SPB appeared as important empathic concern in care situations. Patients expressed many sorts of concerns for others, but also perceived an altered self‐understanding that did not meet mutual expectations within relationships. In SPB associated with WTD three constellations were found: (a) WTD to unburden others; (b) patients decided against hastening death to prevent being a further burden to others (in these cases, the SPB counteracted the wish to die); and (c) both wishes for and against dying were sustained by SPB. These patients often felt paralyzed and suffered deeply. Family caregivers felt emotionally touched by SPB and tried to unburden patients by caring and compassion. We concluded that the impact of SPB on a WTD and the various meanings the facets of SPB have in balancing relationships need to be worked out individually. An early palliative and narrative approach is warranted. (shrink)

German; one contribution each in English and French.

German; one contribution each in English and French.

Fields for Innovative Future Research in History of Science – A Historian of Technology's Perspective. The observations at hand present a historian of technology's perspective and sketch three fields for innovative future research: (past) ‘futures’ and future scenarios in themselves; the challenges as imposed by recent developments in science, technology, and society (e.g. digitization, climate change); and the twisting and flipping of established perspectives (e.g. by focusing on ‘failed’ or ‘old’ science and technology and their declension). Moreover, historians of science, (...) technology, and medicine should participate in emerging transdisciplinary fields such as Environmental Humanities. (shrink)

This article suggests evidence for and reasons why prior acquisition may either facilitate or inhibit acquisition of a new construction. It investigates acquisition of the German passive and future constructions which contain a lexical verb with either the auxiliary sein “to be” or werden “to become”, and are related through these to potential supporting constructions. We predicted that a supported construction should be acquired earlier, faster, and unusually rapidly. An inhibited construction should show an extended depressed usage. We analyzed a (...) dense corpus of a German boy between 2;0 and 5;0. He acquired the sein- before the werden-passive. The former was supported by his prior acquisition of the sein copula, whereas the werden-passive itself supported one werden copula construction. He acquired the werden-future extremely slowly due to the hindrance of a semantically identical construction. These results fit with an emergentist approach in which apparently “sudden” acquisition is still due to gradual learning mechanisms. (shrink)

In this commentary, the core features of the Irish Protection of Life During Pregnancy Act 2013 are outlined. This legislation provides, for the first time in the history of the Irish state, a framework for the provision of lawful abortion in Ireland. The paper will explain the background to the legislation, discuss its main features, and reflect on the likely impact that it will have on the availability of abortion in Ireland.

Direct to consumer genetic testing has given rise to much controversy, especially in relation to testing for health diagnostic purposes. This paper will consider whether consumers' use of DTC genetic testing should be understood as predominantly recreational. It will be argued that recreational testing can encompass all information domains, including most kinds of predictive health risk information. In relation to recreational testing the potential identity implications for the consumer become a significant concern, more so than the risks more traditionally associated (...) with genetic testing. It will be concluded that while the DTC genetic testing sector is beset by numerous problems and an increase in consumers' genetic literacy is highly desirable, consumers' engagement with DTC genetic testing may be less problematic than sometimes assumed. (shrink)

We show that there may be a Milliken-Taylor ultrafilter with infinitely many near coherence classes of ultrafilters in its projection to ω, answering a question by López-Abad. We show that k -colored Milliken-Taylor ultrafilters have at least k +1 near coherence classes of ultrafilters in its projection to ω. We show that the Mathias forcing with a Milliken-Taylor ultrafilter destroys all Milliken-Taylor ultrafilters from the ground model.

Zeitgleich mit Cassirers erstem Band der „Philosophie der symbolischen Formen“ erscheint mit der „Einheit der Sinne. Grundlinien einer Ästhesiologie des Geistes“ das frühe, weithin unbemerkt gebliebene Hauptwerk Helmuth Plessners. Um Plessners schwieriges Werk in seiner Originalität und darin in seiner Aktualität sichtbar zu machen, werden beide Werke als kulturphilosophische ‚Parallelaktion‘ rekonstruiert, der es darum geht, systematisch die Spannweite der menschlichen Symbolwelten zwischen Mythos bzw. Kunst auf der einen, Wissenschaft auf der anderen Seite zu erschließen.

Emotional subjects: Heart. Pathos -- Emotional syntax: Release. Juggle. Acknowledging. Trembling. Broken -- Epilogue: against emotional violence.

For about five decades the phrase "sanctity-of-life" has been part of the Anglo-American biomedical ethical discussion related to abortion and end-of-life questions. Nevertheless, the concept's origin and meaning are unclear. Much controversy is based on the mistaken assumption that the concept denotes the absolute value of human life and thus dictates a strict prohibition on euthanasia and physician-assisted suicide. In this paper, I offer an analysis of the religious and philosophical history of the idea of "sanctity-of-life." Drawing on biblical texts (...) and interpretation as well as Kant's secularization of the concept, I argue that "sanctity" has been misunderstood as an ontological feature of biological human life, and instead locate the idea within the historical virtue-ethical tradition, which understands sanctification as a personal achievement through one's own actions. (shrink)

For about five decades the phrase “sanctity-of-life“ has been part of the Anglo-American biomedical ethical discussion related to abortion and end-of-life questions. Nevertheless, the concept’s origin and meaning are unclear. Much controversy is based on the mistaken assumption that the concept denotes the absolute value of human life and thus dictates a strict prohibition on euthanasia and physician-assisted suicide. In this paper, I offer an analysis of the religious and philosophical history of the idea of “sanctity-of-life.” Drawing on biblical texts (...) and interpretation as well as Kant’s secularization of the concept, I argue that “sanctity” has been misunderstood as an ontological feature of biological human life, and instead locate the idea within the historical virtue-ethical tradition, which understands sanctification as a personal achievement through one’s own actions. (shrink)

We consider a version of \-Miller forcing on an uncountable cardinal \. We show that under \, \, and forcing with \\) collapses \ to \.